Multicenter study of some liver and heart function tests in SARS-Cov-2 patients from three ethnic groups in Iran

Fatahi, Seyed Majid and Razavi Nikoo, Hadi and Safarzadeh, Ali and Talei, Gholam Reza and Khanizadeh, Sayyad (2023) Multicenter study of some liver and heart function tests in SARS-Cov-2 patients from three ethnic groups in Iran. VirusDisease.

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Abstract

The liver and cardiovascular system disorders are not common in COVID-19 patients, but the patients sufering from these complications are exposed to a higher rate of mortality and disease progression. Hepatic injuries can drive to increased levels of liver enzymes, including ALT, AST, and LDH. Abundant levels of AST, LDH, and CPK can be indicators of cardiac injuries. The current study comparise 366 individuals who are divided into COVID-19 patients and healthy individuals groups, in which we have examined hepatic and cardiac function parameters. Moreover, the clinical characteristics of the participants, ethnicities, and their diference with studied parameters were assessed. The results showed Fars individuals are more susceptible to the disease progression, including liver and heart damage. COVID-19 infection is associated with aging, which indicates that the mean age of the case group is ten years older than the control group (P<0.001). The blood sugar in the case group (140.50) was higher than in the control group (131.66), although there was no diference between the infection and BS (P=0.505). Similarly, the increased- mean of the ALT level in the case group (102.369) compared with the control group (68.324) resulted in no signifcant diference (P=0.318). Other parameters, including CPK, LDH, and AST showed an increase in the control group values compared to the case group; however, the diferences were not signifcant (P=0.264, P=0.795, P=0.417). Considering the involvement of cardiac and hepatic organs by SARS-CoV-2, paying particular attention to the disorders of these organs through assessing the hepatic and cardiac function parameters can enhance the patient's recovery and survival. However, in this study, we not observed signifcant diferences, except for the Fars people. There is need for further assessment of this issue.

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