Jafari, Ali and Nazari, Efat and Ghaderpoori, Mansour and Rashidipour, Marzieh and Nazari, Afshin and Chehelcheraghi, Farzaneh and Kamarehie, Bahram and Rezaee, Reza (2024) Loaded paraquaton polymeric nanocapsules and evaluation for cardiotoxicity in Wistar rats. Int J Environ Health Res.
Full text not available from this repository.Abstract
Present work was conducted to prepare and evaluate, loaded paraquat nano-hydrogels using chitosan, sodium polytriphosphate, and xanthan via ionic gelification method. The fabricated L-PQ formulations were analyzed for surface morphology and functional groups using SEM and FTIR, respectively. The stability of the synthesized nanoparticle was, also, analyzed in terms of diameter size, zeta potential, dispersion index, and pH. Furthermore, the cardiotoxicity effects of the synthesized nanogels were investigated on Wistar rats in terms of enzymatic activity, echocardiographic, and histological analysis. The proper stability of the prepared formulation was also confirmed by diameter size, zeta potential, dispersion index, and pH. The efficiency of encapsulation was about 90±3.2% and the release of PQ in the loaded nanogel was about 90±2.3%. A decrease in ST (shortening time) segment by formulated PQ, either in peritoneal or gavage exposure pathway, indicates the effectiveness of the capsule layer against the penetration of toxin into the body.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine R Medicine > RZ Other systems of medicine |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | lorestan university |
| Date Deposited: | 01 Mar 2023 04:55 |
| Last Modified: | 13 Apr 2024 06:46 |
| URI: | http://eprints.lums.ac.ir/id/eprint/4118 |
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