The Roles of microRNA miR-185 in Digestive Tract Cancers

Babaeenezhad, Esmaeel and Hadipour Moradi, Forouzan and Moradi Sarabi, Mostafa and Naghibalhossaini, Fakhraddin (2022) The Roles of microRNA miR-185 in Digestive Tract Cancers. Noncoding RNA.

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Abstract

Digestive tract cancers represent a serious public health issue. In recent years, evidence has accumulated that microRNA miR-185 is implicated in the pathogenesis of this group of highly malignant tumors. Its expression variations correlate with clinical features, such as tumor size, lymph node metastasis, tumor node metastatic stage, survival, recurrence and response to adjuvant therapy, and have diagnostic and prognostic potential. In this review, we compile, evaluate and discuss the current knowledge about the roles of miR-185 in digestive tract cancers. Interestingly, miR-185 is apparently involved in regulating both tumor suppressive and oncogenic processes. We look at downstream effects as well as upstream regulation. In addition, we discuss the utility of miR-185 for diagnosis and its potential concerning novel therapeutic approaches.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 14 Nov 2022 05:28
Last Modified: 14 Nov 2022 05:28
URI: http://eprints.lums.ac.ir/id/eprint/3980

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