Effect of magnesium sulfate on morphine activity retention to control pain after herniorrhaphy

Sedigheh Nadri, Lorestan University of Medical Sciences and Hormoz Mahmoudvand, Lorestan University of Medical Sciences and Sepideh Vahabi, Lorestan University of Medical Sciences (2016) Effect of magnesium sulfate on morphine activity retention to control pain after herniorrhaphy. Pain Manag, 7 (2). pp. 119-125. ISSN 1758-1869

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Abstract

Our research was carried out to compare magnesium sulfate (MgSO4) with isotonic saline in terms of pain control co-administered with morphine after herniorrhaphy. ● Our sample size was 100 patients who were candidates of herniorrhaphy randomized into two groups: experimental and control (50 patients in each). ● Spinal anesthesia was induced using 20% of 4 cc of morphine. ● The experimental and control group were administered after postoperation with 20% of 2 cc MgSO4 in 2 cc of isotonic saline and 4 cc of isotonic saline, respectively. ● Our findings showed that MgSO4 increased the potency of morphine thereby reducing the amount of postoperative pain killer needed. ● This approach to the therapy of surgical pain is a potential mechanism for successful analgesia formulati aim: This research was carried out to compare magnesium sulfate (MgSO4) with isotonic saline in terms of pain control after herniorrhaphy. Patients & methods: A randomized double-blind study, in which the patients were blind to all. A total of 100 patients who were candidates of herniorrhaphy were randomized into two groups: experimental and control (50 patients in each). Anesthesia was induced with 20% of 4 cc of morphine. The experimental and control group received postoperative 20% of 2 cc MgSO4 in 2 cc of isotonic saline and 4 cc of isotonic saline, respectively. Result: The administration of postoperative morphine in control group 0.79 ± 1.48 mg was significantly higher to the experimental group 0.17 ± 0.63 mg during the first 24 h (p = 0.01). conclusion: MgSO4 increased the potency of morphine thereby reducing the amount of postoperative pain killer needed. Keywords • herniorrhaphy • magnesium sulfate • morphine • pain

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