Cardioprotective effects of curcuminloaded magnetic hydrogel nanocomposite (nanocurcumin) against doxorubicin-induced cardiac toxicity in rat cardiomyocyte cell lines

Mehrdad Namdaria, Lorestan University of Medical Sciences and Ali Eatemadi, Tehran University of Medical sciences (2010) Cardioprotective effects of curcuminloaded magnetic hydrogel nanocomposite (nanocurcumin) against doxorubicin-induced cardiac toxicity in rat cardiomyocyte cell lines. Artificial Cells, Nanomedicine, and Biotechnology, 7. pp. 1-9. ISSN 2169-1401

Preview

Text 33.pdf Download (1MB) | Preview

Abstract

ABSTRACT Curcumin, is a yellow substance extracted from Curcuma longa rhizomes, it is a crystalline compound that has been traditionally applied in culinary practices and medicines in India. The aim of our study is to demonstrate the efficacy of curcumin-loaded magnetic hydrogel nanocomposite in the treatment of heart hypertrophy. 10 rats weighing 150–200 g each were induced with heart failure using 2.5mg/kg doxorubicin for 2 weeks. The test groups were treated with curcumin-loaded magnetic hydrogel nanocomposite while the control was treated with curcumin alone. malondialdehyde (MDA) levels, superoxide dismutase (SOD), and glutathione peroxidase (GPX) enzymes activities were monitored after two weeks of last the dose. In addition, the expression of three heart failure markers; atrial natriuretic peptide (ANP), B type natriuretic peptide (BNP), and beta major histocompatibility complex (b-MHC) were observed, it was found that the expression of these markers decreases with an increase in the concentration of curcumin (P<0.05). Curcumin elevated the decreased level of GPX and SOD, and reduced the elevated level of MDA in cardiac tissue. We suggest this combination to be a potent therapy for heart failure and hypertension in the nearest future. KEYWORDS Cardioprotective; curcumin; doxorubicin; cardiac; toxicity

Actions (login required)

View Item