Marzban, Abdolrazagh and ZahraMirzaei, Seyedeh and Karkhane, Maryam and K.Ghotekar, Suresh and Danesh, Abolghasem (2022) Biogenesis of copper nanoparticles assisted with seaweed polysaccharide with antibacterial and antibiofilm properties against methicillin-resistant Staphylococcus aureus. Journal of Drug Delivery Science and Technology.
Full text not available from this repository.Abstract
The use of copper oxide nanoparticles (CuNPs) varies widely, including catalysts, gas sensors, batteries, solar energy converters, magnetic storage media, and heterogeneous applications. However, green-synthesized CuNPs have drawn greater interest for their potential biomedicines. The present study is aimed to synthesize CuNPs using water-soluble polysaccharides (SPs) extracted from brown seaweed, Sargassum vulgare (S. vulgare). The fabrication of CuNPs followed the extraction of SPs and characterization of their compositions. To characterize the CuNPs, UV-VIS, SEM, TEM, EDX, FTIR, and XRD measurements were performed. Additionally, SPs-CuNPs were evaluated for antimicrobial, antibiofilm, and free radical scavenging properties. According to the UV–visible spectroscopy, the SPs-CuNPs showed a maximum surface plasmon resonance (SPR) peak at 305.1 nm. FTIR spectroscopy indicated the possible functional groups associated with the formation of CuNPs. SEM and TEM revealed that SPs-CuNPs were spherical and ranged in size from 40 to 50 nm. Based on XRD and EDX, the size of the crystallites was estimated to be 36.3 nm, and their elemental compositions were found to be 2:1 Copper to Oxygen (Cu2O). DPPH and H2O2 scavenging activities of SPs-CuNPs were approximately 88% and 71%, respectively. The MIC values for SPs-CuNPs against S. aureus MRSA and MSSA were 250 and 150 μg/ml, respectively. The SPs-CuNPs exhibited the greatest biofilm inhibition against S. aureus MRSA and MSSA at 100 and 50 g/ml, respectively. Given these results, SPs-CuNPs can be used as an alternative therapy for microorganisms that have developed antibiotic resistance. Thus, further studies into the mode of action and possible side effects of SPs-CuNPs would improve their potential for use as an antimicrobial drug.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RZ Other systems of medicine |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | samira sepahvandy |
| Date Deposited: | 09 Jul 2022 02:50 |
| Last Modified: | 09 Jul 2022 02:50 |
| URI: | http://eprints.lums.ac.ir/id/eprint/3847 |
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