Keikhosravi, Navid and Dehghan-Ghahfarokhi, Esmaeil and Abdollahi, Soosan and Piramoon, Majid and Javad Ghasemian-Yadegari, Majid and Rezaeinasab, Rezvan (2022) Solvent-free Synthesis and Antimicrobial Activity of Dihydroquinazolinone Derivatives. Journal of Medicinal and Chemical Sciences.
Full text not available from this repository.Abstract
In this research, a new series of dihydroquinazolinone analogs (۴a-f) was synthesized using a one-pot reaction supporting solvent-free conditions at the presence of SnCl۲.۲H۲O as catalyst. All final products were proved by FT-IR, ۱H-NMR, and ۱۳C-NMR analysis. The preliminary antimicrobial activity was assessed against Gram-negative (Escherichia coli, Pseudomonas aeruginosa), Gram-positive (Staphylococcus aureus, Bacillus subtilis, Lactobacillus rhamnosus), and antifungal activities against Candida albicans. Most of the synthesized derivatives revealed considerable activity, significantly compounds ۴d and ۴e at ۰.۲۵ mg/mL concentration had the highest activity against P. aeruginosa. Also, the MIC of compound ۴d was ۰.۲۵ mg/mL against B. subtilis, and L. rhamnosus. Furthermore, the tested molecules demonstrated moderate antifungal activities against the C. albicans.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RZ Other systems of medicine |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | lorestan university |
| Date Deposited: | 07 May 2022 04:16 |
| Last Modified: | 07 May 2022 04:16 |
| URI: | http://eprints.lums.ac.ir/id/eprint/3752 |
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