MiR-1307: A comprehensive review of its role in various cancer

Saberianpou, Shirin and Abkhooie, Leila (2022) MiR-1307: A comprehensive review of its role in various cancer. Gene Reports.

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Abstract

Various investigations have indicated that miRNAs play a critical role in a wide range of biological functions, like cell differentiation, metabolism of energy, proliferation, and apoptosis. MiRNAs are significantly dysregulated in cancerous cells and malignancies. It has been demonstrated miRNA has two functions in cancer progression: it can stimulate carcinogenesis by blocking tumor suppressors or it functions as a tumor suppressor by helping down-regulation of oncogenes. MiR-1307, which has been recently discovered as a cancer-associated miRNA, is considered a risk factor for the development of metastatic types of cancers. MiR-1307 levels in serum are increased in breast cancer and can be used to diagnose the disease early. Data show that miR-1307-3p is an oncogenic miRNA with a significant contributory role in the development and progression of the thorough targeting SMYD4. Furthermore, this miRNA helps to the proliferation of cancer cells include of breast, ovarian, colorectal, lung, and so on. MiR-1307 overexpress in gastric cancer cell lines and its interaction with DAB2 protein lead to promote the behavior of tumoral cells such as proliferation and migratory and metastasis. In hepatocellular carcinoma (HCC) miR-1307-3p promotes HCC proliferation, invasion, and advancement by reducing DAB2 protein. In ovarian cancer, miR-1307 influence the cell cycle of tumoral cells and decline the response to chemotherapy drugs in ovarian cancer by regulation of the CIC (capicua transcriptional repressor) gene. Another mechanism for miR-1307-3p was seen in colon adenocarcinoma miR-1307-3p can be bind to the 3′-untranslated area of TUSC5 and control progression and metastasis of colon adenocarcinoma cells. MiR-1307-5p can binds to TRAF3 and stimulates the NF-B/MAPK pathway to enhance the proliferation of lung tumor. In this review study, we try to recapitulate the role of miR-1307 in the process of pathogenesis and treatment of various cancers according to recently published studies.

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