In silico approach to predict the SARS-CoV-2 derived candidate MiRNAs as a potential antiviral therapy

Mohammadi, Shiva and Kavousipour, Soudabeh and Eftekhar, Ebrahim and Jalili, Sajad and Arabizadeh, Elham (2021) In silico approach to predict the SARS-CoV-2 derived candidate MiRNAs as a potential antiviral therapy. Current Drug Therapy.

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Background: The coronavirus disease 2019 (COVID-19) is a contagious disease originating from Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Previous experimental studies indicated that during viral infections, viral miRNAs (vmiRNAs) played key roles in pathogen-host interaction, immune escape, host cell death, and tumorigenesis. MiRNAs are small, single-stranded RNAs that exist in viruses as well as in animals. Thus, these molecules can play a pivotal role in viral disease pathogenesis. Objective: Since no approved drugs or vaccines currently exist for SARS-CoV-2 and its pathogenic mechanism is unknown, the present study aimed to explore and propose vmiRNA platforms as potential antiviral therapeutic agents against SARS-CoV-2. The development of antiviral drugs to target vmiRNAs may result in the down-regulation of viral virulence genes expression and suppression of viral proliferation. Methods: In this study, to attain insight into the potential role of SARS-CoV-2-derived miRNAs in viral infections, a set of computational methods was used to scan the SARS-CoV-2 genome, eventually predicting 13 potential candidate vmiRNAs. Furthermore, the potential genes were predicted in the human hosts that were the target of these candidate vmiRNAs by applying the mirPath software. Results: This study proposed a theory indicating that the predicted vmiRNAs might have a plausible role in altering human target gene expression, mainly contributing to a viral infectious state, inflammation, and immune system escape. These vmiRNAs might have therapeutic trends as antiviral agents against COVID-19 infection. Conclusion: The findings offered a reference idea for a supplementary study on miRNA identification as a drug target and revealed the necessity to increase the understanding of SARS-CoV-2 genome structure for a better combat against the virus

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 19 Dec 2021 05:40
Last Modified: 19 Dec 2021 05:40

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