Study of B3A2 fusion which is the most common mutation of ABL-BCR in chronic myeloid leukemia patients in Lorestan Province

Kiani, Ali Asghar and Ahmadi, Kolsom and Heydari nazarabad, Vhideh and Bahmani, Banafsheh and Gorgi*, Mojtaba (2016) Study of B3A2 fusion which is the most common mutation of ABL-BCR in chronic myeloid leukemia patients in Lorestan Province. Yafte, 18 (3).

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Abstract

Background: Diagnosis of Chronic myeloid leukemia (CML) is according to the existence of ABL_BCR fusions and Philadelphia chromosome. Various type of ABL_BCR fusions were studied on 58 cml patients. Materials and Methods: Blood samples were obtained with informed consent after completing basic information. RNA was extracted from blood samples and cDNA was synthesized. By multiplex RT-PCR method, ABL-BCR fusions containing b3a2 and b2a2, e1a2 and b3a2 were studied. Results: From 58 patients, who were positive ABL_BCR fusion, 18 patients (30.5 %) with fusion b2a2, 37 patients (71/62%) have b3a2 fusion and three (08/3 percent) fusion's e1a2 respectively. In this study 25 men and 33 women participated. In contrast with other studies, women with (CML) had more population than men in this study. Conclusion: The results of the ABL-BCR fusion in the Lorestan province (with the exception of higher prevalence in women) were same to the other studies in Iran and b3a2 fusion has the highest prevalence in the patients were studied. Keywords: Chronic myeloid leukemia, Philadelphia chromosome, ABL-BCR fusion, Lorestan.

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