Moradi Sarabi, Mostafa and Amini, Maral and Kaviani, Mozhgan and Babaeenezhad, Esmaeel and Naghibalhossaini, Fakhraddin (2021) Bilirubin and Epigenetic Modifications in Metabolic and Immunometabolic Disorders. Endocr Metab Immune Disord Drug Targets.
Full text not available from this repository.Abstract
Bilirubin is the main waste product of heme catabolism. At high concentrations, bilirubin may cause toxicity, especially in the brain, kidney, and erythrocytes. Membrane and mitochondrial dysfunction, oxidative stress, apoptosis, necrosis, endoplasmic reticulum stress, excitotoxicity, inflammation, and epigenetic modifications are the main mechanisms of toxicity triggered by bilirubin in susceptible organs. Many studies have shown that there is an interaction between bilirubin and epigenetic modifications in metabolic and immune diseases. In this review, we first outline the toxicity mediated by bilirubin and then summarize the current knowledge linking bilirubin and epigenetic modifications in metabolic and immunometabolic disorders.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | lorestan university |
| Date Deposited: | 28 Nov 2021 04:26 |
| Last Modified: | 28 Nov 2021 04:26 |
| URI: | http://eprints.lums.ac.ir/id/eprint/3356 |
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