Gold nanoparticles: Multifaceted roles in the management of autoimmune disorders

Koushki, Khadijeh and Keshavarz Shahbaz, Sanaz and Keshavarz, Mohsen and Sahebkar, Amirhossein and Sathyapalan, Thozhukat (2021) Gold nanoparticles: Multifaceted roles in the management of autoimmune disorders. Biomolecules.

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Gold nanoparticles (GNPs) have been recently applied for various diagnostic and therapeutic purposes. The unique properties of these nanoparticles (NPs), such as relative ease of synthesis in various sizes, shapes and charges, stability, high drug-loading capacity and relative availability for modification accompanied by non-cytotoxicity and biocompatibility, make them an ideal field of research in bio-nanotechnology. Moreover, their potential to alleviate various inflammatory factors, nitrite species, and reactive oxygen production and the capacity to deliver therapeutic agents has attracted attention for further studies in inflammatory and autoimmune disorders. Furthermore, the characteristics of GNPs and surface modification can modulate their toxicity, biodistribution, biocompatibility, and effects. This review discusses in vitro and in vivo effects of GNPs and their functionalized forms in managing various autoimmune disorders (Ads) such as rheumatoid arthritis, type 1 diabetes, and multiple sclerosis. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 14 Sep 2021 06:32
Last Modified: 14 Sep 2021 06:32

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