Effect of Combined Extracts of Mummy, Withania Coagulans, and Turmeric on the Repair and Treatment of Bone Fractures in Rats

Habibollahi*, Mohammadhossein and Abdollahi gonbaj, Arezoo and Ansari Moghaddam, Alireza and Rigi, Amir and Sanjarani, Ali and Talebrohi, Maryam (2021) Effect of Combined Extracts of Mummy, Withania Coagulans, and Turmeric on the Repair and Treatment of Bone Fractures in Rats. Yafteh, 23 (3).

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Abstract

Background: Repair of broken bones due to physiological or pathological factors has always been important for researchers. In this regard, this study aimed to evaluate the effect of a combined extract on the osteogenic process in the experimental fracture created in the femoral of rats as laboratory models. Materials and Methods: This experimental study was performed on 21 rats. After induction of general anesthesia to each mouse, a 3-cm incision was made in the femoral bone and it was broken with a special hammer. After surgery, the control group did not receive any extract, while the three experimental groups received 200, 500, and 1000 mg/kg PO, respectively. In the next step, 21 days after surgery, euthanasia was performed and bone sections were prepared and stained in the fracture site. Next, histopathological and histomorphometric studies were carried out for the evaluation of bone healing in rats. The collected data were analyzed in SPSS software (version 21). Results: According to the pairwise comparison test, the mean difference of variables, namely bone marrow, woven bone, and lamellar bone of the third group of the test was significantly different from those of the other groups (P<0.05). This indicated that receiving the extract in the experimental groups with an increased dose led to a decrease in the mean bone marrow and woven bone which, in turn, increased the mean lamellar bone. Conclusion: The results showed that the combined extracts of mummy, Withania coagulans, and turmeric can stimulate osteogenesis in rats and be considered as a candidate for fracture treatment. Keywords: Bone fracture, Mummy, Rat, Turmeric, Withania coagulans.

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