Bio-inspired silver selenide nano-chalcogens using aqueous extract of Melilotus ofcinalis with biological activities

Mirzaei, Seyedeh Zahra and Esmaeil Lashgarian, Hamed and Karkhane, Maryam and Marzban, Abdolrazagh and Shahzamani, Kiana and Alhameedaw, Alaa Kamil (2021) Bio-inspired silver selenide nano-chalcogens using aqueous extract of Melilotus ofcinalis with biological activities. Bioresources and Bioprocessing.

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Abstract

For the frst time, an aqueous extract of Melilotus ofcinalis was used to synthesize bimetallic silver selenide chalcogenide nanostructures (Ag2Se-NCs). The formation of NCs was confrmed and characterized by UV–visible and FTIR spectroscopy, SEM and TEM imaging, XRD and EDX crystallography, zeta potential (ZP) and size distribution (DLS). The bioactivities of biosynthesized Ag2Se-NCs, such as antibacterial, antibioflm, antioxidant and cytotoxicity potentials, were then examined. Bio-based Ag2Se-NCs were successfully synthesized with mostly spherical shape in the size range of 20–40 nm. Additionally, the MIC and MBC values of Ag2Se-NCs against β-lactam-resistant Pseudomonas aeruginosa (ATCC 27853) were 3.12 and 50 µg/ml, respectively. The DPPH scavenging potential of Ag2Se-NCs in terms of IC50 was estimated to be 58.52. Green-synthesized Ag2Se-NCs have been shown to have promising benefts and could be used for biomedical applications. Although the fndings indicate promising bioactivity of Ag2Se-NCs synthesized by M. ofcinalis extract (MO), more studies are required to clarify the comprehensive mechanistic biological activities.

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