Beneficial Effects of Omega 3 and Vitamin E Co-Administration on Gene Expression of SIRT1 and PGC1α and serum antioxidant enzymes in patients with Coronary Artery Disease

Djalali, Mahmoud and Yousefi Rad, Esmaeil and Saboori, Somayeh and Koohdani, Fariba and Nematipour, Ebrahim and Saboor-Yaraghi, Ali Akbar and Javanbakht, Mohammad Hassan and Eshraghian, Mohammad Reza and Ramezan, Atena Beneficial Effects of Omega 3 and Vitamin E Co-Administration on Gene Expression of SIRT1 and PGC1α and serum antioxidant enzymes in patients with Coronary Artery Disease. Nutrition, Metabolism and Cardiovascular Diseases.

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Abstract

Background and Aim: SIRT1 and PGC1α are two important genes which play critical roles in regulating oxidative stress and inflammation processes. The aim of this study was to assess the effects of omega 3 and vitamin E supplement co-administration on SIRT1 and PGC1α gene expression and serum levels of antioxidant enzymes in CAD patients. Methods and Results: Participants of this randomized controlled trial included 60 CAD male patients who received omega 3 (4g/day) and vitamin E placebo (OP), omega 3 (4g/day) and vitamin E (400IU/day) (OE) or omega 3 and vitamin E placebos (PP) for two months. Gene expression of SIRT1 and PGC1α in Peripheral Blood Mononuclear Cells (PBMCS) was assessed using RT-PCR. Furthermore, serum antioxidant enzymes and hsCRP were assessed at the beginning and the end of the intervention. Gene expression of SIRT1 and PGC1α increased significantly in OE group (P =0.039 and P= 0.050, respectively). Catalase and hsCRP increased significantly in OE and OP groups. GPX and SOD did not statistically change in all groups. TAC increased significantly in OE group (P=0.009), but not in OP and PP groups. Conclusion: Combination of omega 3 fatty acids with vitamin E may have beneficial effects on CAD patients by increasing gene expression of SIRT1 and PGC1α and improving oxidative stress and inflammation in these patients. Keywords: CAD, omega 3, vitamin E, SIRT1, PGC1α, antioxidant enzymes

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: sobhan rezaiian
Date Deposited: 01 Oct 2016 07:35
Last Modified: 01 Oct 2016 07:35
URI: http://eprints.lums.ac.ir/id/eprint/288

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