Yarahmadi, Mohsen and Bazyar, Hadi and Gravand, Ehsan and Haghighizade, Mohammad Hossein and Zare Javid, Ahmad (2021) A randomized double-blind clinical trial: the effectiveness of daily synbiotic supplementation in management of metabolic and periodontal status and inflammatory markers in type-2 diabetes mellitus patients with periodontal disease under nonsurgical-periodontal-therapy. Journal of Social Sciences.
Full text not available from this repository.Abstract
Aim: The purpose of this study was to determine the effectiveness of daily synbiotic supplement in management of patients with type 2 diabetes mellitus (T2DM) and periodontal disease (PD) under non-surgical periodontal therapy (NSPT). Methods: In this clinical trial, 50 patients suffering from diabetes and periodontal disease were recruited and randomly assigned to two groups: intervention group (n= 25), one capsule/day synbiotic (500 mg) and control group (n=25) received one capsule/day placebo (500 mg) for 8 weeks. Results: Synbiotic supplement with NSPT significantly decreased serum levels of FBG, HbA1c, TNF-α, IL-6 and mean of periodontal status indexes including pocket depth (PD) and clinical attachment loss (CAL) and also decreased plaque index, compared with the baseline (all p < 0.05). In addition, a significant difference in the mean of PD, plaque and bleeding on probing (BOP) indexes was observed between two groups after the intervention (all p < 0.05). Furthermore, LDL-c levels significantly decreased compared with the baseline value in both groups (all p < 0.05). Also, the mean changes of IL-6 were significantly lower in the intervention group in compare with the control group after the adjustment of confounding factors (p = 0.01). Conclusions: Synbiotic supplementation with NSPT may be beneficial in improving patients with T2DM and periodontal disease.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RK Dentistry |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | samira sepahvandy |
| Date Deposited: | 01 Jun 2021 06:24 |
| Last Modified: | 01 Jun 2021 06:24 |
| URI: | http://eprints.lums.ac.ir/id/eprint/2800 |
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