Synergetc effects of Chick Embryo Extract and Gold Nanopartcles for Matching Skin Flap Regeneraton

Chehelcheraghi, Farzaneh (2021) Synergetc effects of Chick Embryo Extract and Gold Nanopartcles for Matching Skin Flap Regeneraton. Nanomed Res J.

NMRJ_Volume 6_Issue 1_Pages 41-49.pdf

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Background and objectve: In the present paper, impacts of gold Nanopartcles (AUNPs) and Chick Embryo Extract Therapy (CEET) were investgated on the wound healing promotng propertes that match the dynamic healing process of skin flap regeneraton. Methods: AUNPs were developed using the high-intensity short-pulse beams mode of neodymium-doped: Ytrium, Aluminum, and Garnet photoablaton method. Also, 45-µg extract from a 4-6 day chick embryo was used as a protein source for CEET. Dorsal Random Skin Flaps (RSFs) were created in forty-fve Albino Wistar rats and they were accidentally assigned to 3 groups; G(C); group did not receive any treatment (control), G (AUNP); treated only with AUNPs, and G(CE+AUNP) the rats treated with AUNPs and CEET. During a random skin flap animal model, AuNPs and CE were used as solutons and convenient to deliver into the skin flap. The skin flap survival rate was evaluated in the following by a camcorder, and tssue studies were done at days 3, 6, and 9 afer surgery by the hematoxylin & eosin and Masson trichrome staining. Result: Rats treated with the AUNPs and CEET exhibited remarkably increased flap survival than the others. Tissue studies showed that AUNPs and CEET caused inducton of forming the new blood vessels and stmulated the inflammatoncausing reacton in an inital phase of wound healing. Conclusion: Using AUNPs with CEET increases the potental for a dynamic recovery of skin flap regeneraton.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 12 Apr 2021 05:35
Last Modified: 12 Apr 2021 05:35

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