Dose-response meta-analysis of arsenic exposure in drinking water and hypertension

Amiri, Afsaneh and Mokhayeri, Yaser and Mohammadi, Rasool and Karami, Mohammad Amin and Ghaderpoori, Mansour and Kamarehie, Bahram and Jafari, Ali (2021) Dose-response meta-analysis of arsenic exposure in drinking water and hypertension. Heliyon.

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Background: Based on the cross-sectional and cohort studies, exposure to As via drinking water can cause hypertension. Methods: We searched PubMed, ISI WOS, and Scopus for relevant studies up to 1 January 2018 using related keywords. The meta-analysis was done on 10 studies (n ¼ 28255) that report Odds Ratio for hypertension. The extracted ORs between As concentration and hypertension were pooled using random effect models. Study heterogeneity was analyzed using I2. Results: The estimated adjusted OR for association between As and hypertension was 1.44 (95% CI: 1.12, 1.84) with I2 ¼ 71%. Dose-Response analysis showed a linear relationship between As and hypertension (OR ¼ 1.0008 95% CI: 1.0003, 1.001). In general, by increase of each unit in arsenic concentration, odds of the hypertension would increase as 0.08%. Conclusion: There was a significant relationship between As exposure and hypertension.

Item Type: Article
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 12 Apr 2021 04:05
Last Modified: 12 Apr 2021 04:05

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