Magnesium intake, insulin resistance, and markers of endothelial function among women

Ghorbani Bavani, Narges and Falahi, Ebrahim and Sadeghi, Omid and Esmaillzadeh, Ahmad (2021) Magnesium intake, insulin resistance, and markers of endothelial function among women. Public Health Nutrition.

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Objective: We investigated the association of dietary magnesium intake with insulin resistance and markers of endothelial function among Iranian women. Design: A cross-sectional study. Setting: Usual dietary intakes were assessed using a validated food frequency questionnaire. Dietary magnesium intake was calculated by summing up the amount of magnesium in all foods. A fasting blood sample was taken to measure serum concentrations of glycemic indices (fasting plasma glucose and insulin) and endothelial function markers (E-selectin, soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1). Insulin resistance and sensitivity were estimated using the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), Homeostasis Model Assessment β-cell function (HOMA-β) and quantitative insulin sensitivity check index (QUICKI), respectively. Participants: Iranian female nurses (n=345) selected by a multistage cluster random sampling method. Results: The magnesium intake across energy-adjusted quartiles was 205±7 (mean±SE), 221.4±8, 254.3±7 and 355.2±9 mg/d, respectively. After adjustments for potential confounders, QUICKI level was significantly different across quartiles of magnesium intake (Q1: 0.34±0.02, Q2: 0.36±0.01, Q3: 0.40±0.01, Q4: 0.39±0.02, P=0.02); however, this association disappeared after considering markers of endothelial function; indicating that this relation might be mediated through endothelial dysfunction. After controlling for all potential confounders, magnesium intake was inversely, but not significantly, associated with serum concentrations of sICAM (Q1: 239±17, Q2: 214±12, Q3: 196±12, Q4: 195±17, P=0.29). There was no other significant association between dietary magnesium intake and other indicators of glucose homeostasis or endothelial markers. Conclusions: Higher dietary magnesium intake was associated with better insulin sensitivity in Iranian females. This linkage was mediated through reduced endothelial dysfunction.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 04 Apr 2021 08:43
Last Modified: 04 Apr 2021 08:43

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