The Relationship between Helicobacter Pylori and Extra-Gastrointestinal Infections

Nazer, Mohamad Reza and Darvishi, Mohammad and Noori, Majid and Soleiman-Meigooni, Saeed and Forootan, Mojgan (2021) The Relationship between Helicobacter Pylori and Extra-Gastrointestinal Infections. Iranian Journal of Medical Microbiology.

Iran J Med-v14n6p543-en.pdf

Download (1MB) | Preview


Helicobacter pylori (H. pylori) has been identified as the major agent in human gastric cancer by the International Agency for Research on Cancer (IARC). Infection caused by H. pylori plays a leading role in many disorders including duodenal and gastric ulcer, chronic gastritis, lymphoid tissue lymphoma, and gastric adenocarcinoma. In addition, growing evidence suggests that H. pylori interferes with many biological processes, causing or affecting the incidence of several extra-gastrointestinal disorders. The bacteria are known to cause iron deficiency anemia (IDA), vitamin B12 deficiency, and immune thrombocytopenic purpura (ITP). Latest studies suggest that H. pylori may contribute in many disorders such as insulin resistance, acute coronary syndrome, neurological diseases among others, which previously was attributed to other factors and conditions. There are several mechanisms proposed for H. pylori inducing low-grade chronic inflammation and the incidence of molecular imitation mechanisms. This present study discusses the most critical diseases related with the role of H. pylori and related infection (especially extra-gastrointestinal diseases) in these diseases.

Item Type: Article
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 06 Feb 2021 04:33
Last Modified: 06 Feb 2021 04:33

Actions (login required)

View Item View Item