n vivo: maternal betaine supplementation normalized fetal growth in diabetic pregnancy

Salahi, Pouya and Gharabaghi, Mahdiyeh and Rocky, Alireza and Alirezaei, Masoud (2020) n vivo: maternal betaine supplementation normalized fetal growth in diabetic pregnancy. Archives of Gynecology and Obstetrics.


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Purpose Diabetes alters maternal metabolism and can lead to aberrant fetal growth. In addition to insulin treatment, nutritional diet interventions are recommended for promoting fetal health against diabetes-induced adverse efects. Therefore, we conducted an in vivo study to investigate betaine efcacy on fetal development against maternal diabetes. Methods Thirty-two dams were divided into four equal groups: control (C), betaine supplementation (BS), diabetic pregnancy (DP) and diabetic pregnancy plus betaine supplementation (DP + BS). Fasting blood sugar (FBS) and body weight (BW) were monitored during pregnancy. After physiological delivery, dams glycated hemoglobin (HbA1c) concentrations were measured, followed by fetal development indices including litter size (LS), neonatal weight (NW) and crown-rump (CR). Also, maternal oxidative status was assessed by evaluating glutathione (GSH) content, glutathione peroxidase (GSHPx) and catalase (CAT) activities, and malondialdehyde (MDA) concentration in the erythrocytes. Results Betaine supplementation signifcantly alleviated FBS and tended to recover BW loss. It also signifcantly decreased HbA1c values in dams of DP + BS compared to DP group. Normalized fetal indices such as LS, NW and CR under betaine supplementation were associated with a signifcant increase in GSH content and GSH-Px activity, as well as decreased MDA concentrations in erythrocytes of dams in the DP+ BS versus the DP group, indicating improved redox balance in the dams. Conclusion We indicated for the frst time that betaine supplementation improved the maternal glucose metabolism and redox balance associated with normalized fetal growth. Nevertheless, further studies are required to investigate the mechanisms through which betaine protects fetal growth in diabetic pregnancy

Item Type: Article
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 19 Dec 2020 04:50
Last Modified: 19 Dec 2020 04:50
URI: http://eprints.lums.ac.ir/id/eprint/2510

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