‎ Comparison of oxidative stress indices in pregnant women with and without ‎gestational diabetes mellitus(Article)‎

Asadian, Payman and Haghighat,, S‎ and Naghshineh,, E‎ and Haghighat,, F‎ (2019) ‎ Comparison of oxidative stress indices in pregnant women with and without ‎gestational diabetes mellitus(Article)‎. Journal of Isfahan Medical School.

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Background: Oxidative stress, defined as a disturbance in the balance between the ‎production of reactive oxygen species (free radicals) and antioxidant defenses, is ‎discussed in relation to its possible role in the production of tissue damage in diabetes ‎mellitus. Regarding the prevalence of gestational diabetes mellitus in recent decades and ‎the results of some studies about the effect of nutritional anomalies and oxidative stress, ‎as well as insufficiency of studies on its occurrence, this study aimed to compare of ‎oxidative stress indices in women with and without gestational diabetes mellitus. Methods: ‎In a case-control study conducted in Isfahan Health Center No. 2, Isfahan, Iran, in 2017-‎‎2018, 37 women with gestational diabetes mellitus and 53 women without it mellitus were ‎selected using convenient sampling method. Oxidative stress indices including ‎glutathione (GSH), total antioxidant capacity, superoxide dismutase, non-esterified fatty ‎acids (NEFA), catalase, and malondialdehyde were measured and compared between ‎the two groups. Findings: The mean total antioxidant capacity was 441.6 ± 63 and 562.5 ‎‎± 44.9 µmol/l in women with and without gestational diabetes mellitus, respectively (P = ‎‎0.011). The mean catalase level in the two groups was 0.32 ± 1.12 and 1.79 ± 0.59 U/l, ‎respectively, and the difference between the two groups was statistically significant (P = ‎‎0.024), but the other factors were not significantly different between the women with and ‎without gestational diabetes mellitus. Conclusion: The levels of some oxidative stress ‎markers such as total antioxidant capacity and catalase were significantly higher in ‎women with gestational diabetes mellitus. Therefore, oxidative stress seems to play a role ‎in the pathogenesis of gestational diabetes.‎

Item Type: Article
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 16 Dec 2020 15:20
Last Modified: 16 Dec 2020 15:20
URI: http://eprints.lums.ac.ir/id/eprint/2501

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