Antibiotic Susceptibility Evaluation of ‎Bacterial Agents Causing Infection in ‎Children with Acute Tonsillopharyngitis

Sherkatolabbasieh, Hamidreza and Firouzi, Majid and Shafizadeh, Shiva and Amiri, Iman (2020) Antibiotic Susceptibility Evaluation of ‎Bacterial Agents Causing Infection in ‎Children with Acute Tonsillopharyngitis. Infect Disord Drug Targets.

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Background: The aim of this study is to evaluate the prevalence of group A beta-‎hemolytic pharyngitis by assessing the outcome of the culture and the resistance and ‎sensitivity of group A beta hemolytic streptococcus to antibiotics.‎ Methods: This cross-sectional study was conducted on 170 patients, aged 3-15 years, ‎referred to the clinic with complaints of sore throat. Patients' history was collected and ‎physical examination was performed and were score based on clinical findings. Patients ‎with other underlying pathologies and those taking antibiotics prior to the study were ‎excluded from our study. Antimicrobial susceptibility test was performed by disk diffusion ‎method against cephalexin, cefazolin, erythromycin and amoxicillin.‎ Results: A total of 170 patients were reported with sore throat. Patients with positive ‎culture results were 60% male and 40% female. Amoxicillin resistance was the greatest ‎‎(5%) in the culture. All isolated bacteria were sensitive to amoxicillin, cephalexin, cefazolin ‎and erythromycin. Patients with McIssac score ≥ 6 showed clinical sensitivity 75% ‎specificity 61% negative predictive value 94.8% and positive predictive value 20.3% for ‎Group A beta-hemolytic streptococcal pharyngitis.‎ Conclusion: The results showed the higher the clinical score, the greater the chance of ‎positive throat culture.‎ Keywords: Antibiotic Susceptibility; Beta-hemolytic streptococcus Group A; MsIssac; ‎Tonsillopharyngitis; bacterial resistance; pharyngitis; scoring‎

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 16 Dec 2020 15:03
Last Modified: 16 Dec 2020 15:03

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