In vitro and ex vivo antiparasitic effect of Rheum ‎ribes L. extract against the hydatid cyst ‎protoscoleces

Mahmoudvand, Hossein and Saki, Mojgan and Kiani, Ali Asghar and Taban, Tina and Shahmoradi, Mohammad Kazem (2020) In vitro and ex vivo antiparasitic effect of Rheum ‎ribes L. extract against the hydatid cyst ‎protoscoleces. Infect Disord Drug Targets.

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Background: Cystic echinococcosis is a zoonotic infection in humans and herbivorous ‎animals with worldwide distribution which caused by larva stage of Echinococcus ‎granulosus. Rhubarb (Rheum ribes L.) as an herbal medicines has various therapeutics ‎properties such as the antioxidant, anticancer, and antimicrobial ones. With respect to the ‎potential of the biological activities of this plant in traditional and modern medicine, we ‎aim to examine its protoscolicidal effects against E. granulosus protoscolecess in vitro and ‎ex vivo.‎ Methods: Collected protoscoleces from liver hydatid cysts of infected sheep were ‎exposed to the different concentrations of the extract (225, 450, 900 mg/mL) for 5-60 min ‎in vitro and ex vivo. Then using the eosin exclusion assay the viability of protoscoleces was ‎studied.‎ Results: R. ribes extract had a potent protoscolicidal activity in vitro so that at the 450 and ‎‎900 mg/ml killed 56.3 and 100% of protoscoleces after 10 min exposure. Ex vivo assay, ‎the extract needed more time to kill the protoscoleces than the in vitro; so that at the ‎concentration of 900 mg/mL, all protoscoleces were killed after 15 minutes.‎ Conclusion: The obtained results exhibited the potent protoscolicidal effects of R. ribes ‎extract particularly at the concentration of 900 mg/ml which completely killed the parasite ‎after <15 min exposure. However, more and supplementary studies are required to verify ‎these findings through assessing in animal models and clinical subjects.‎

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 16 Dec 2020 14:57
Last Modified: 16 Dec 2020 14:57

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