Evaluation of Ischemic Heart Disease Factors in ‎Hemophilia Patients in Khorramabad

Nezami, Ali Reza and Tarhani, Fariba and Elahi, Sina (2020) Evaluation of Ischemic Heart Disease Factors in ‎Hemophilia Patients in Khorramabad. Cardiovasc Hematol Disord Drug Targets.

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Background: Evaluation of risk factors associated with coronary artery disease and cardiac health in ‎hemophilia patients is necessary to prevent the onset of ischemic heart disease. In this study, we evaluated ‎the cardiovascular status of hemophilic patients in Lorestan province for the early onset of ischemic heart ‎disease.‎ Methods: In this cross-sectional descriptive study, a total of 80 patients presenting severe hemophilia, the ‎detailed questionnaire-based investigation was conducted to analyze the prevalence of cardiovascular risk ‎factors in severe hemophilic patients. In patients with hemophilia, body mass index (BMI), blood pressure, ‎diabetes, LDL, cholesterol and HDL, the risk of cardiovascular death was estimated using a predictive risk ‎predictor algorithm of Europe SCORE.‎ Results: The mean age of the patients was 25 years where all the patients were non-diabetic. ‎Echocardiography did not show any wall motion abnormality and changes in the T wave and dysrhythmia ‎was also not seen by ECG. 7 patients had high blood pressure, 11 had abnormal HDL, and 1 had abnormal ‎LDL. In this study, serum LDL and HDL levels were not significantly correlated with age and BMI. Conversely, ‎age and BMI were significantly associated with hypertension. Hypertension was observed in people over ‎the age of 25 years and in overweighed individuals.78.8% had normal BMI and 21.3% were overweighed. ‎There was no significant correlation between serum LDL, serum HDL, and blood pressure and sex. The ‎levels of abnormal LDL and HDL were higher in men than in women.‎ Conclusion: ECG findings from our study did not report any significant cardiac abnormalities among ‎hemophilic patients. Cardiovascular risk factors were not significantly correlated in these paitents.‎ Keywords: Cardiovascular Disease; Europe SCORE.; Hemophilia; Ischemic Heart Disease; Risk Factor; non-‎diabetic.‎

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 16 Dec 2020 05:27
Last Modified: 16 Dec 2020 05:27
URI: http://eprints.lums.ac.ir/id/eprint/2464

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