Maternal circulating status of vitamin D, adiponectin and lipid ratios in gestational diabetes mellitus

Khosrowbeygi, Ali and Ahmadvand, Hassan (2020) Maternal circulating status of vitamin D, adiponectin and lipid ratios in gestational diabetes mellitus. Clinical Diabetology.

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Abstract

ABSTRACT Background. The present research was an attempt to assess maternal serum values of 25-hydroxy vitamin D 3 [25(OH)D3], adiponectin and the lipid ratios and comparison of their associations with insulin resistance and insulin sensitivity in gestational diabetes mellitus (GDM). Material and methods. It was conducted on 100 participants including 49 women with GDM and 51 normal pregnant women at 24–28 weeks of gestation. Maternal fasting serum values of glucose, 25(OH)D3, lipid profle, adiponectin and insulin were assessed and the lipid ratios and biomarkers of resistance and sensitivity to insulin were calculated. Statistical signifcance was set at P < 0.05. Results. Current research revealed that levels of 25(OH) D 3 were signifcantly lower in GDM than in normal pregnancy. Binary logistic regression analysis showed that GDM was associated negatively with 25(OH)D3, HDL-C and adiponectin and positively with the lipid ratios. Multiple linear regression analysis showed that only values of 25(OH)D3 were independently associated negatively with the insulin resistance (P = 0.012). Conclusions. Levels of 25(OH)D3 were signifcantly decreased in GDM compared with normal pregnancy. On the other hand, 25(OH)D3 had a signifcant negative correlation with insulin resistance which was stronger than the lipid ratios and adiponectin. (Clin Diabet 2020; 9; 5: 321–327) Key words: vitamin D, gestational diabetes, adiponectin, insulin resistance

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