Sarvestani, Amirmehdi and Karimian, Ali and Mohammadi, Rasool and Cheraghipour, Kourosh and Zivdri, Masoomeh and Almasian, Mohammad and Nafari, Amirhossein (2020) Scolicidal effects of Cassia fistula and Urtica dioica extracts on protoscoleces of hydatid cysts. J Parasit Dis.
Full text not available from this repository.Abstract
Abstract Echinococcosis is among the most underestimated parasitic diseases that have universal distribution. The primary treatment is surgery. Hence, the development of new and more effective scolicidal agents with lower side effects is crucial. This study evaluated the therapeutic effects of Urtica dioica and Cassia fistula extracts as a scolicidal herbal drug in vitro. Suspension of protoscoleces was obtained from the infected livers of sheep in Khorramabad, Iran. Hydro-alcoholic solution was extracted from the leaves and stems of Urtica dioica and the fruit of Cassia fistula. Echinococcus granulosus protoscoleces were treated with the essential oils at concentrations of 10, 25, 50, and 100 mg/mL for 10, 20, 30, and 60 min and their viability was evaluated by the eosin staining test. The extract of Urtica dioica at a concentration of 100 mg/mL killed 90.51% of protoscoleces after 60 min. Cassia fistula also killed 67.74% of protoscoleces after 60 min. This study obtained satisfactory results. Urtica dioica and Cassia fistula extracts are promising protoscolicides and can be used in the treatment of hydatid cysts and presurgically to prevent secondary infections. Keywords Echinococcus granulosus Cystic echinococcus Protoscolex Hydatid cyst Protoscolicidal activity Cassia fistula Urtica dioica
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | lorestan university |
| Date Deposited: | 14 Dec 2020 05:50 |
| Last Modified: | 14 Dec 2020 05:50 |
| URI: | http://eprints.lums.ac.ir/id/eprint/2440 |
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