The Effect of Hirodoid Cream on Ecchymosis and Edema around Eyes after Rhinoplasty

Rostami, Khalil and Shahaboddin, Mohammad Ali and Niazi, Feizollah and Nadri, Sedigheh and Mahmoudvand, Hormoz and Karimi Rouzbahani, Arian (2020) The Effect of Hirodoid Cream on Ecchymosis and Edema around Eyes after Rhinoplasty. World J Plast Surg.

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Abstract

BACKGROUND Several methods have been used to decrease the periorbital edema and ecchymosis after rhinoplasty. In this study, we evaluated the efcacy of hirudoid and dexamethasone in reduction of the periorbital edema and ecchymosis. METHODS Sixty patients who underwent primary rhinoplasty were randomly divided into 3 groups. Group H received hirudoid cream, 3 times per day for 5 days from postoperative-day (POD). Group D received 10 mg of dexamethasone IV, immediately before surgery; and group C (control) received neither dexamethasone nor hirudoid. Two surgeons who were unaware of administered medications rated the severity of edema and intensity of ecchymosis, on 2nd, 5th, and 7th POD. RESULTS On 2nd POD, the edema in group D was signifcantly lower than groups H and C; but there was no signifcant difference in severity and intensity of ecchymosis between 3 groups. On 7th POD, the intensity of ecchymosis was signifcantly lower in group H in comparison to group C. When the difference between 2nd and 7th POD was evaluated, the resolution of severity of edema and intensity of ecchymosis was signifcantly better in group H (p<0.001). CONCLUSION Hirudoid was shown to be effective in reducing edema and ecchymosis after rhinoplasty. The use of dexamethasone was effective in prevention of periorbital edema at early postoperative days, but it was not effective on resolution of ecchymosis. KEYWORDS Hirodoid; Ecchymosis; Edema; Periorbital; Eye; Rhinoplasty

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