Asbaghi, Omid and Ghanbari, Niloofar and Shekari, Mahdi (2020) The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials. Clinical Nutrition ESPEN.
Full text not available from this repository.Abstract
So far, no study has summarized the findings on the effects of berberine intake on anthropometric parameters, C-reactive protein (CRP) and liver enzymes. This systematic review and meta-analysis were done based upon randomized controlled trials (RCTs) to analyze the effects of berberine on anthropometric parameters, CRP and liver enzymes. Method Following databases were searched for eligible studies published from inception to 30 July 2019: MEDLINE, EMBASE, Web of Science, Cochrane Library, PubMed and Google scholar. Necessary data were extracted. Data were pooled by the inverse variance method and expressed as mean difference with 95% Confidence Intervals (95% CI). Result 12 studies were included. Berberine treatment moderately but significantly decreased body weight (WMD = −2.07 kg, 95% CI -3.09, −1.05, P < 0.001), body mass index (BMI) (WMD = −0.47 kg/m2, 95% CI -0.70, −0.23, P < 0.001), waist circumference (WC) (WMD = −1.08 cm, 95% CI -1.97, −0.19, P = 0.018) and C-reactive protein (CRP) concentrations (WMD = −0.42 mg/L, 95% CI -0.82, −0.03, P = 0.034). However, berberine intake did not affect liver enzymes, including alanine aminotransferase (ALT) (WMD = −1.66 I/U, 95% CI -3.98, 0.65, P = 0.160) and aspartate aminotransferase (AST) (WMD = −0.87 I/U, 95% CI -2.56, 0.82, P = 0.311). Conclusion This meta-analysis found a significant reduction of body weight, BMI, WC and CRP levels associated with berberine intake which may have played an indirect role in improved clinical symptoms in diseases with metabolic disorders. Berberine administration had no significant effect on ALT and AST levels.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RC Internal medicine |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | samira sepahvandy |
| Date Deposited: | 16 Aug 2020 04:44 |
| Last Modified: | 16 Aug 2020 04:44 |
| URI: | http://eprints.lums.ac.ir/id/eprint/2272 |
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