The potentials of immune checkpoints for the treatment of blood malignancies

Alizadeh, Mohsen and Safarzadeh, Ali and Hoseini, Seyed Ali and Piryaei, Reza (2020) The potentials of immune checkpoints for the treatment of blood malignancies. Crit Rev Oncol Hematol.

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Immune checkpoints are the regulators of the immune system, which include stimulatory and inhibitory receptors. They play substantial roles in the maintenance of immune system homeostasis and the prevention of autoimmunity and cancer. In the current review, immune checkpoints roles are surveyed in the initiation, progression, and treatment of blood malignancies. The significant roles of immune checkpoints are discussed as clinical markers in the diagnosis and prognosis of a plethora of blood malignancies and also as potential targets for the treatment of these malignancies. It could be concluded that the regulation of immune checkpoints in various blood cancers can be employed as a novel strategy to obtain effective results in leukemia treatment and introduce immune checkpoint inhibitors as sufficient weapons against blood cancers in the future.

Item Type: Article
Subjects: R Medicine > RB Pathology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 13 Jul 2020 03:52
Last Modified: 13 Jul 2020 03:52

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