Betaine alleviated hepatic and renal injury in diabetic pregnant rats: biochemical and histopathological evidences

Salahi, Pouya and Rocky, Alireza and Dezfoulian, Omid and Azizi, Afsaneh and Alirezaei, Masoud (2020) Betaine alleviated hepatic and renal injury in diabetic pregnant rats: biochemical and histopathological evidences. Journal of Diabetes & Metabolic Disorders.

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Abstract

Purpose Pregnancy is the most intense physiological alteration in energy metabolism that women experience in their lifetime. Liver and kidney are the two most susceptible organs to energy metabolism. Diabetes is well-defined as a syndrome interfering withenergymetabolismtriggeredbyimpairedbloodglucoseadjustment.Herein,protectiveeffectsofbetaineonliverandkidney were evaluated in animal model of diabetic pregnancy. Methods 32damswereassignedinto4equal groups:Control (C),Betaine(B,1.5%w/woftotal dietdaily),Diabeticpregnancy (D), and Diabetic pregnancy treated with betaine (D+B). After physiological delivery, HbA1c concentration in whole blood, serum hepatic and renal biomarkers such as AST, ALT, ALP, urea and creatinine were measured. Also, liver and kidney tissue samples were examined under a light microscope. Results Diabetic pregnancy was found to be accompanied by increased HbA1c level, concentration of hepatic and renal biomarkers in blood samples, and a gamut of alterations such as apoptotic cells, biliary hyperplasia, sinusoidal dilation, basement membrane thickening, and Bowman’s capsule dilation as observed in histopathological sections of the D group. Betaine supplementation significantly decreased AST, ALT, urea and creatinine in the D+B group compared to D group. Also, most of pathologic microscopic alterations were attenuated under betaine treatment in D+B group compared to D group. Conclusion Findingsofthecurrentpaper,forthefirsttime,providedevidenceregardingprotectiveeffectsofbetaineonliverand kidney function against maternal diabetes in an animal model of STZ-induced diabetic pregnancy.

Item Type: Article
Subjects: R Medicine > RB Pathology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 22 Jun 2020 03:51
Last Modified: 22 Jun 2020 03:51
URI: http://eprints.lums.ac.ir/id/eprint/2192

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