The effects of supplementation with L-arginine on anthropometric indices and body composition in overweight or obese subjects: A systematic review and meta-analysis

Zeinali Khosroshahi, Mohammad and Asbaghi, Omid and Moradi, Sajjad and Jalili, Cyrus (2020) The effects of supplementation with L-arginine on anthropometric indices and body composition in overweight or obese subjects: A systematic review and meta-analysis. Journal of Functional Foods.

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Abstract

Background: Animal studies have shown that L-Arginine can affect anthropometric and body composition indices favorably, while results of human studies are contradictory. Objective: This is a meta-analysis of human studies in which L-arginine was provided as a dietary supplement to test its effects on anthropometric indices. Design: Wesearched the Cochrane library, PubMed, Embaseand Scopus databases to identify studies in which Larginine was provided to humans in randomized clinical trials. Results: Of 4784 publications, 12 trials were included for the meta-analysis. Pooled effect sizes indicated that Larginine significantly reduced body mass index (BMI), waist circumference (WC), and fat mass (FM), and also increased fat-free mass (FFM) compared to the placebo group. However, the effects of L-arginine on body weight (BW) was not significant. Subgroup analysis could not identify factors significantly influencing BW. Conclusion: We found a beneficial effect of L-arginine supplementation on anthropometric indices in overweight and obese subjects

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