Hepatitis C Virus Alternative Reading Frame Protein (ARFP): Production, Features and Pathogenesis

Mohamadi, Mahdi and Azarbayjani, Mohammad Ali and Ajorloo, Mehdi (2020) Hepatitis C Virus Alternative Reading Frame Protein (ARFP): Production, Features and Pathogenesis. J Med Virol.

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Earlier observation suggests that Hepatitis C virus (HCV) is a single-stranded RNA virus which encodes at least 10 viral proteins. F protein is a novel protein which has been discovered recently. These studies suggest 3 mechanisms for the production of this protein concerning ribosomal frameshift at codon 10, initial translation at codon 26, and 85 or 87. In this study, the association between protein F and chronicity of hepatocellular carcinoma (HCC) has been reviewed. Evidence suggests that humoral immune system can recognize this protein and produce antibodies against it. By detecting antibodies in infected people, investigators found that F protein might have a role in HCV infection causing chronic cirrhosis and hepatocellular carcinoma as higher prevalence was found in patients with mentioned complications. The increment of CD4+, CD25+ and FoxP3+ T cells, along with CD8+ T cells with low expression of granzyme B, also leads to weaker responses of the immune system which helps the infection to become chronic. Moreover, it contributes to the survival of the virus in the body through affecting the production of interferon. F protein also might play roles in the disease development, resulting in hepatocellular carcinoma. The existence of F protein affects cellular pathways through upregulating p53, c-myc, cyclin D1 and phosphorylating Rb (pRb). This review will summarize these effects on immune system and related mechanisms in cellular pathways. This article is protected by copyright. All rights reserved. Keywords: ARFP; F protein; HCV; Hepatitis C virus; alternative reading frame

Item Type: Article
Subjects: R Medicine > RB Pathology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 31 May 2020 05:37
Last Modified: 31 May 2020 05:37
URI: http://eprints.lums.ac.ir/id/eprint/2136

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