Cirrhosis-induced morphological changes in the retina: possible role of endogenous opioid

Delfan, Bahram and Amiri nghashlaghi, Saeed and Algazo, Mohammad abdolla and Hassanzadeh, Gholamreza and Sabbagh ziarani, Fatemeh and Jazaeri, Farahnaz and Dehpour, Ahmad reza (2015) Cirrhosis-induced morphological changes in the retina: possible role of endogenous opioid. Int J ophtalmol, 8 (4).

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Abstract

·AIM: To investigate the impact of cirrhosis on retinal morphology and to evaluate the role of endogenous opioids as a mediator in cirrhosis induced retinal change. ·METHODS: Thirty -six male rats were divided into 3 main groups; the common bile duct ligated (BDL) group, the sham-operated (Sham) group and the unoperated (Unop) group. Then each of these three main groups was divided into two subgroups; the first subgroup received daily injection of naltrexone hydrochloride (NTX) and the second group was injected with normal saline (Saline) daily. After 28d, rats were anesthetized and their right eyes were enucleated and assessed for histological changes. The thickness of the rod and cons layer, outer nuclear layer, outer plexiform layer, inner nuclear layer, inner plexiform layer and ganglion cell layer for each eye were measured in micrometers by light microscope.eliminated when naltrexone hydrochloride was injected. These results suggest a possible role for endogenous opioids in the morphological retinal changes detected in cirrhotic rats. · KEYWORDS: cirrhosis; endogenous opioids; retina; ganglion cell layer

Item Type: Article
Subjects: R Medicine > RE Ophthalmology
Depositing User: sobhan rezaiian
Date Deposited: 28 Sep 2016 05:56
Last Modified: 28 Sep 2016 07:00
URI: http://eprints.lums.ac.ir/id/eprint/212

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