Asadolahi, p and Farzan, Behrooz and Rezaei, Faranak and Delfani, Somayeh and Ashrafi, Behnam and Soroush, Setareh (2020) First Report on the Characteristics of Methicillin Resistant Staphylococcus Capitis Isolates and a NRCS-A-clone Related Isolate Obtained from Iranian Children. Infect Disord Drug Targets.
Full text not available from this repository.Abstract
Methicillin-resistant Staphylococcus capitis (MRSC) NRCS-A clone (Multi-resistant and vancomycin-non susceptible) has been recently described as an emerging cause of nosocomial bacteremia especially in neonatal intensive-care units (NICUs). OBJECTIVE: The objective of this study was to evaluate the antibiotic and antiseptic resistance patterns, biofilm producing ability and the prevalence of SCCmec and ACME types among MRSC isolates as well as to check the possible presence of NRCS-A clone at Tehran's Children's Medical Center, Iran. METHODS: A total of 256 coagulase negative Staphylococcal isolates were collected, of which 10 S. capitis isolates were obtained and tested for susceptibility against 13 antimicrobial and 3 antiseptic agents, as well as biofilm production. The presence of 15 distinct resistance genes, staphylococcal cassette chromosome mec (SCCmec), and arginine catabolic mobile elements (ACMEs) were tracked. RESULTS: Seven out of 10 S. capitis isolates were MRSC (MIC90 van=8μg/mL) and resistant to trimethoprim/sulfamethoxazole, produced biofilm, (3 as strong biofilm producers) and carried ACME types I and II. Despite the identification of mec and ccr complexes in some isolates, all the SCCmec cassettes were untypeable (UT). CONCLUSION: According to the studied features, only one isolate belonged to the NRSC-A clone. The results indicate that MRSC with high antibiotic resistance and unknown SCCmec might become a serious problem in the future for the treatment of patients particularly children.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RB Pathology |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | samira sepahvandy |
| Date Deposited: | 18 May 2020 04:25 |
| Last Modified: | 18 May 2020 04:25 |
| URI: | http://eprints.lums.ac.ir/id/eprint/2103 |
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