Theeffectofsaffronsupplementationonbloodglucoseandlipidprofile:A systematicreviewandmeta-analysisofrandomizedcontrolledtrials

Asbaghi, Omid and Soltani, Sepideh and Choobkar, Saeed and Norouzi, Noushin (2019) Theeffectofsaffronsupplementationonbloodglucoseandlipidprofile:A systematicreviewandmeta-analysisofrandomizedcontrolledtrials. ComplementaryTherapiesinMedicine.

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Abstract

Background: Despite several studies about the effects of saffron supplementation on serum concentrations of lipid and glucose profiles, no systematic study had summarized the findings. Therefore, we conduct current studytosystematicallysummarizefindingsfromstudiesabouttheeffectofsaffronsupplementationonserum levelsofglucoseandlipidprofilesandtodoameta-analysis,ifpossible. Methods: A systematic literature search was conducted for clinical trials published in PubMed, SCOPUS, EMBASE,Cochrane'sLibraryandISIWebofSciencefromthebeginningto22February2019.Allrandomized clinicaltrialsontheeffectofsaffronsupplementationonserumconcentrationsoflipidandglucoseprofileswere included. Results: Inoverall,sixstudieswereincludedinthecurrentstudy.Pooledanalysisofsixstudiesfortheeffectof saffron on serum TG, TC and FBG concentrations and of five studies for LDL and HDL, showed a significant reductioninTG(WMD:-8.93mg/dl;95%CI:-16.49to-1.37,P=0.02)andTClevels(WMD:-5.72mg/dl;95% CI: -11.10 to -0.34, P=0.03), a significant increase in HDL levels (WMD: 2.7 mg/dl; 95% CI: 0.22 to 5.18, P=0.03), and no significant effect on LDL (WMD: -2.30 mg/dl; 95% CI: -11.73 to 7.13, P=0.63) and FBG levels(WMD:-5.30mg/dl;95%CI:-14.20to3.60,P=0.51). Conclusion: WefoundasignificantreductioninserumconcentrationsofTCandTGandasignificantincreasein serum levels of HDL following supplementation with saffron. Saffron supplementation had no significant influenceonserumFPGandLDLconcentrations.

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