Cancer stem cells and nanotechnological approaches for eradication

Basati, Gholam and Khaksarian, Mojtaba and Abbaszadeh, Saber and Esmaeil Lashgarian, Hamed and Marzban, Abdolrazagh (2019) Cancer stem cells and nanotechnological approaches for eradication. Stem Cell Investig.


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Abstract: Cancer stem cells (CSCs) are currently known as the main cause of tumor recurrence. After chemotherapy is completed, CSCs proliferate and then differentiate to generate new tumor tissues. Similar to normal stem cells, this non-uniformly distributed cell population in the tumor tissue has selfrenewal capacity and is responsible for survival of the tumor and difference in its genetic and metabolic characteristics. Followed by gene instability in CSCs, new phenotypic markers are aberrantly expressed in CSCs subpopulation. Hence, some of the surface markers and metabolic pathways that are upregulated in CSCs may be applied as specific targets for development of diagnostic and therapeutic approaches. In this review article, the distinctive properties of CSCs including signal pathways implicated in self-renewal and surface markers were discussed. Moreover, targeting CSCs based on their specific properties using nanodrugs was reviewed. Keywords: Cancer stem cells (CSCs); self-renewal; nano-formulations; surface markers

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 10 May 2020 04:55
Last Modified: 10 May 2020 04:55

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