Sleep and frailty risk: a systematic review and meta-analysis

Pourmotabbed, Ali and Boozari, Behnoosh and Babaei, Atefeh and Asbaghi, Omid (2020) Sleep and frailty risk: a systematic review and meta-analysis. Sleep and Breathing.

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Abstract

Abstract Purpose Studies on the association between sleep and frailty risk have yielded contradictory outcomes. Therefore, a systematic review and meta-analysis were designed to examine the relationship between sleep and frailty risk. Methods Relevant studies were identified bysearching PubMed, Embase, and Scopus databases until 30November 2019. Data were available from ten studies. Selected articles were published between 2009 and 2019. The odds ratios of 41,233 individuals were used for the meta-analysis. Results Pooled analysis demonstrated that when compared to the reference category of 6 to 8 hours nightly sleep duration, both thehighestcategory(morethan8hours,OR1.21;95%CI1.10–1.32)andlowestcategoryofsleep(under6hours,OR1.13;95%CI 1.08–1.18), were significantly correlated with increased risk of frailty. Furthermore, daytime drowsiness (OR 1.25; 95% CI 1.02–1.52), sleep disordered breathing (OR 1.28; 95% CI 1.03–1.58), and prolonged sleep latency (OR 1.18; 95% CI 1.06–1.31) enhancedtheriskoffrailty.Subgroupanalysesbyfrailtystatussuggestthatashortersleepdurationwasassociatedwithriskoffrailty but not pre-frailty. However, prolonged sleep time was significantly related with enhanced risk of pre-frailty and frailty. In addition, subgroup analyses via sex revealed that longer and shorter sleep durations increased risk of frailty in both men and women. Conclusion The present study revealed that longer and shorter sleep durations are associated with increased risk of frailty. Keywords Sleep .Frailty .Systematicreview .Meta-analysis

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