The fluctuations of metabotropic glutamate receptor subtype 5 (mGluR5) in the Amygdala in fear conditioning model of male Wistar rats following sleep deprivation, reverse circadian and napping

Kordestani-Moghadam, parastou and Nasehi, M and Khodagholi, Fariba (2020) The fluctuations of metabotropic glutamate receptor subtype 5 (mGluR5) in the Amygdala in fear conditioning model of male Wistar rats following sleep deprivation, reverse circadian and napping. Journal Pre-proofs.

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Abstract

Sleep is involved in metabolic system, mental health and cognitive functions. Evidence shows that sleep deprivation (SD) negatively affects mental health and impairs cognitive functions, including learning and memory. Furthermore, the metabotropic glutamate receptor subtype 5 (mGluR5) is a metabolic biomarker, which is affected by various conditions, including stress, sleep deprivation, and cognitive and psychiatric disorders. In this research, we investigated the effect of SD and reverse circadian (RC), and two models of napping (continuous and non-continuous) combined with SD or RC on fear-conditioning memory, anxiety-like behavior and mGluR5 fluctuations in the amygdala. 64 male Wistar rats were used in this study. The water box apparatus was used to induce SD/RC for 48 hours, and fear-conditioning memory apparatus was used to assess fear memory. The results showed, fearconditioning memory was impaired following SD and RC, especially in contextual stage. However, anxiety-like behavior was increased. Furthermore, mGluR5 was increased in the left amygdala more than the right amygdala. Additionally, continuous napping significantly improved fear-conditioning memory, especially freezing behavior. In conclusion, following SD and RC, fear-conditioning memory in contextual stage is more vulnerable than in auditory stage. Furthermore, increase in anxiety-like behavior is related to increase in the activity of left amygdala and mGluR5 receptors.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: sobhan rezaiian
Date Deposited: 24 Feb 2020 04:27
Last Modified: 24 Feb 2020 04:27
URI: http://eprints.lums.ac.ir/id/eprint/1979

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