The Role of Distinct Tumor Micro-Environments in the Heterogeneity of Metabolic Tumor Phenotypes

Pirmoradi, Saeid and Dariushnejad, Hassan and Ghorbanzadeh, Vajihe and Esmaeil Lashgarian *, Hamed (2020) The Role of Distinct Tumor Micro-Environments in the Heterogeneity of Metabolic Tumor Phenotypes. Yafteh, 21 (4).

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Abstract

Tumorigenesis is a complex and dynamic process. The microenvironment of tumors plays a pivotal role in the formation, initiation and progression of tumors. Studies on neoplastic developments focusing on tumor microenvironment events demonstrate its significance in promoting tumor progression. Prior to tumor metastasis, primary tumors secrete factors that create a proper metabolic environment for tumor metastasis. These conditions prepare the microenvironment for better and more efficient tumor growth. On the other hand, tumor cells continuously interact with the surrounding microenvironment, and targeting the tumor microenvironment can complement traditional treatment and improve the therapeutic outcomes for these malignancies. In the present article, the researchers attempt to highlight the importance of tumor microenvironment in tumorigenesis and tumor metabolism. Keywords: tumor microenvironments, metabolic phenotypes, fatty acid oxidation, metabolic process

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