AnewseriesofSchiff basederivatives bearing 1,2,3‐triazole: Design,synthesis,moleculardocking, and α‐glucosidase inhibition

Nasli‐Esfahani, Ensieh and Mohammadi‐Khanaposhtani, Maryam and Rezaei, Sepideh and Sarrafi, Yaghoub and Mahdavi, Mohammad (2019) AnewseriesofSchiff basederivatives bearing 1,2,3‐triazole: Design,synthesis,moleculardocking, and α‐glucosidase inhibition. arch pharm - dphg.

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Abstract

A series of new Schiff bases bearing 1,2,3‐triazole 12a‒o was designed, synthesized, and evaluated as α‐glucosidase inhibitors. All the synthesized compounds showed promising inhibition against α‐glucosidase and were more potent than the standard drug acarbose. The kinetic study on the most potent compound 12n showed that this compound acted as a competitive α‐glucosidase inhibitor. The docking study revealed that the synthesized compounds interacted with the important residues in the active site ofα‐glucosidase. KEYWORDS 1,2,3‐triazole, antidiabetic activity, molecular docking, Schiff base, α‐glucosidase

Item Type: Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samad darabian
Date Deposited: 15 Feb 2020 06:05
Last Modified: 15 Feb 2020 06:05
URI: http://eprints.lums.ac.ir/id/eprint/1949

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