The effect of omega-3 fatty acids and vitamin E co-supplementation on glycemic profile: A systematic review and meta-analysis of randomized controlled trials

Asbaghi, omid and Saboori, somayeh and Falahi, ebrahim and Salehpour, shadab and Yousefi Rad, esmaeil and Abdollahpour, foad and Ojani, Z (2020) The effect of omega-3 fatty acids and vitamin E co-supplementation on glycemic profile: A systematic review and meta-analysis of randomized controlled trials. Obesity Medicine.

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Abstract

Aims: The aims of this meta-analysis study were to assess the effects of omega 3 fatty acids plus vitamin E co-supplementation on blood glucose, serum insulin and HOMA-IR levels in clinical trial studies. Methods: A systematic literature search was performed for seeking clinical trial studies published in ISI web of Science, Cochrane library, Scopus, PubMed and Embase databases from the beginning up to June 2019. From 802 retrieved papers found in the first step of the search after deleting duplicate findings, nine studies with eight arms included in this meta-analysis for pooling the effects of omega 3 fatty acids plus vitamin E co-supplementation on glycemic profile levels. Results: Results of pooled random-effect size analysis of eight trials revealed significant reducing effects of omega 3 plus vitamin E co-supplementation on blood glucose (WMD: -5.57 mg/l, 95% CI, −8.64, −2.5; P < 0.001), serum insulin (WMD: −3.35 μUI/mL; 95% CI: −4.83, −1.87, p < 0.001) and HOMA-IR (WMD: −1.14; 95% CI: −1.66, −0.63, p < 0.001) levels. The subgroup analysis results showed that baseline levels of glycemic profile, omega-3 Dosage and Type and metabolic status of the patients could not influence intervention results. Conclusion: Results of current meta-analysis study showed that omega 3 fatty acids and vitamin E co-supplementation can beneficially affect glycemic profile levels including blood glucose, serum insulin and HOMA-IR levels.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: sobhan rezaiian
Date Deposited: 21 Jan 2020 04:43
Last Modified: 21 Jan 2020 04:43
URI: http://eprints.lums.ac.ir/id/eprint/1913

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