Effects of selenium supplementation on serum C reactive protein level: A systematic review and meta-analysis of randomized controlled clinical trials

Asbaghi, Omid and Saboori, Somayeh and Hekmatdoost, Azita and Abdollahpour, Foad and Yousefi Rad, Esmaeil and Salehpour, Shadab (2020) Effects of selenium supplementation on serum C reactive protein level: A systematic review and meta-analysis of randomized controlled clinical trials. Obesity Medicine.

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Abstract

Aims: This meta-analysis study aimed to assess effects of selenium supplementation on serum C-reactive protein (CRP) levels in randomized controlled clinical trial studies. Methods: A systematic literature search on clinical trial studies was performed in PubMed, Embase, Scopus, Cochrane'sLibraryandISIWebofSciencedatabasesuptoJune2018,whichwascompletedbymanualsearching of the reference lists of all included studies. From 533 articles retrieved in the first step of the search after excluding duplicate findings, only 14 trials with 22 effect sizes were included for pooling the effects of selenium supplementation on serum CRP level with 1082 and 1080 participants in the intervention and control groups, respectively. Results: Results of random effects model meta-analysis showed a non-significant reducing effect of selenium supplementation on serum CRP levels (WMD: −0.31 mg/l; 95% CI: −0.63, 0.01; P = 0.06). The results of subgroup analysis showed that selenium supplementation could only decrease significantly serum CRP levels, when the dosage of selenium supplementation is 200 μg/day (WMD: −0.52 mg/l; 95% CI = −1.04, −0.01; P = 0.043), when the trial duration is > 8 weeks (WMD: −1.01 mg/l; 95% CI = −1.88, −0.15; P = 0.021), and when the baseline level of CRP is > 3 mg/l (WMD: −2.02 mg/l; 95% CI = −2.87, −1.18; P < 0.001). Conclusion: In conclusion, results of this meta-analysis study showed that selenium supplementation can reduce significantly serum CRP level especially in patients with elevated CRP levels.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: sobhan rezaiian
Date Deposited: 20 Jan 2020 11:12
Last Modified: 20 Jan 2020 11:12
URI: http://eprints.lums.ac.ir/id/eprint/1909

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