A new series of Schiff base derivatives bearing 1,2,3-triazole: Design, synthesis, molecular docking, and α-glucosidase inhibition

Nasli-Esfahani, E and Mohammadi-Khanaposhtani, M and Rezaei, S and Sarrafi, Y and Sharafi, Zeinab (2019) A new series of Schiff base derivatives bearing 1,2,3-triazole: Design, synthesis, molecular docking, and α-glucosidase inhibition. Archiv der Pharmazie, 352 (8).

Full text not available from this repository.

Abstract

A series of new Schiff bases bearing 1,2,3-triazole 12a-o was designed, synthesized, and evaluated as α-glucosidase inhibitors. All the synthesized compounds showed promising inhibition against α-glucosidase and were more potent than the standard drug acarbose. The kinetic study on the most potent compound 12n showed that this compound acted as a competitive α-glucosidase inhibitor. The docking study revealed that the synthesized compounds interacted with the important residues in the active site of α-glucosidase

Item Type: Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samad darabian
Date Deposited: 08 Sep 2019 03:44
Last Modified: 08 Sep 2019 03:44
URI: http://eprints.lums.ac.ir/id/eprint/1800

Actions (login required)

View Item View Item