Nasli-Esfahani, E and Mohammadi-Khanaposhtani, M and Rezaei, S and Sarrafi, Y and Sharafi, Zeinab (2019) A new series of Schiff base derivatives bearing 1,2,3-triazole: Design, synthesis, molecular docking, and α-glucosidase inhibition. Archiv der Pharmazie, 352 (8).
Full text not available from this repository.Abstract
A series of new Schiff bases bearing 1,2,3-triazole 12a-o was designed, synthesized, and evaluated as α-glucosidase inhibitors. All the synthesized compounds showed promising inhibition against α-glucosidase and were more potent than the standard drug acarbose. The kinetic study on the most potent compound 12n showed that this compound acted as a competitive α-glucosidase inhibitor. The docking study revealed that the synthesized compounds interacted with the important residues in the active site of α-glucosidase
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | lorestan university |
| Date Deposited: | 08 Sep 2019 03:44 |
| Last Modified: | 08 Sep 2019 03:44 |
| URI: | http://eprints.lums.ac.ir/id/eprint/1800 |
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