Abbaszadeh, Abolfazl and Tehmasebi-Foolad, A and Rajabzadeh, A and Beigi-Brojeni, N and Zarei, L (2019) Effects of Chitosan/Nano Selenium Biofilm on Infected Wound Healing in Rats; An Experimental Study. Bull Emerg Trauma, 7 (3).
Full text not available from this repository.Abstract
OBJECTIVE: The present study was aimed at assessment of effect of application of Chitosan/Nano Selenium biofilm on infected wound healing in rats. METHODS: Sixty-eight male Wistar rats were randomized into four groups of 17 animals each. In group I (Normal) the wounds were created with no infection. In group II (MRSA), the wounds were infected with methicillin resistant Staphylococcus aureus (MRSA). In group III (MRSA/CHIT), animals with infected wounds were dressed with chitosan biofilm only. In group IV (MRSA/CHIT/NS), animals with infected wounds were dressed with Chitosan/Nano Selenium biofilm. RESULTS: There were significant differences in comparisons of group IV and other groups, particularly in terms of cellular infiltration and neovascularization. During the study period, scores for neovascularization was significantly higher in group IV rats than other groups (P<0.05). Polymorphonuclear (PMN) and mononuclear (MNC) cell count and fibroblast cell proliferation in group IV were significantly higher than those of other experimental groups (P<0.05). CONCLUSION: Chitosan/Nano Selenium biofilm resulted in significant improvement in histopathological indices in full thickness infected wound healing.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RZ Other systems of medicine |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | samira sepahvandy |
| Date Deposited: | 28 Aug 2019 04:22 |
| Last Modified: | 28 Aug 2019 04:22 |
| URI: | http://eprints.lums.ac.ir/id/eprint/1775 |
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