Nasli‐Esfahani, Ensieh and Mohammadi‐Khanaposhtani, Maryam and Sepideh, Rezaei and Sarrafi, Yaghoub and Sharafi, Zeinab and Samadi, Nasser and Faramarzi, Mohammad Ali and Bandarian, Fatemeh and Hamedifar, Haleh and Larijani, Bagher and Hajimiri, Mirhamed and Mahdavi, Mohammad (2019) A new series of Schiff base derivatives bearing 1,2,3‐triazole: Design, synthesis, molecular docking, and α‐glucosidase inhibition. Acta pharm.
Full text not available from this repository.Abstract
A series of new Schiff bases bearing 1,2,3‐triazole 12a‒o was designed, synthesized, and evaluated as α‐glucosidase inhibitors. All the synthesized compounds showed promising inhibition against α‐glucosidase and were more potent than the standard drug acarbose. The kinetic study on the most potent compound 12n showed that this compound acted as a competitive α‐glucosidase inhibitor. The docking study revealed that the synthesized compounds interacted with the important residues in the active site of α‐glucosidase.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | lorestan university |
| Date Deposited: | 19 Aug 2019 05:39 |
| Last Modified: | 19 Aug 2019 05:39 |
| URI: | http://eprints.lums.ac.ir/id/eprint/1746 |
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