Effect of a session of intensive exercise with ginseng supplementation on histone H3 protein methylation of skeletal muscle of nonathlete men

Naghavi moghadam, A and Shiravand, Mustafa and Rezapour, Sadegh and Khoshdel, A and Bazgir, B and Mardani, Mahnaz (2019) Effect of a session of intensive exercise with ginseng supplementation on histone H3 protein methylation of skeletal muscle of nonathlete men. Molecular Genetics and Genomic Medicine, 7 (5).

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Abstract

Purpose: The pressure and stress caused by some intense exercises cause changes in histone proteins and gene expression. The aim of this study was to investigate the effect of one session of intensive exercise with supplementation of ginseng, on the methylation of H3K-36 histone protein in skeletal muscle of young nonathlete men. Methods: After the approval by the ethics committee, 12 untrained male subjects were randomly assigned to either exercise group (six subjects) or exercise and supplement group. First, from both groups, the muscular sample was taken from the broad-lateral muscle of the subjects. Immediately after the muscle biopsy, exercise and exercise + supplement groups completed the exercise protocol. During this period, the exercise + supplement group consumed ginseng supplementation and took placebo group. Immediately after exercise, all subjects were retested. Results: There was no significant increase in histone H3-k36 protein methylation in the intergroup between exercise + supplementation and exercise. There was a significant difference within the training group but there was no difference in the exercise + supplementation group. Conclusion: The methylation caused by intense physical pressure, can be reduced by ginseng extract.

Item Type: Article
Subjects: R Medicine > RZ Other systems of medicine
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: sobhan rezaiian
Date Deposited: 20 May 2019 07:25
Last Modified: 20 May 2019 07:25
URI: http://eprints.lums.ac.ir/id/eprint/1723

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