Oxidative Stress Status and Liver Markers in Coronary Heart Disease

Cheraghi, Mostafa and Ahmadvand, Hassan and Maleki, Ali and Babaeenezhad, Esmaeel and Shakiba, Salman and Hassanzadeh, Fatemeh (2019) Oxidative Stress Status and Liver Markers in Coronary Heart Disease. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 8 (1). pp. 49-55.

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Background: Oxidative stress plays an important role in the development of atherosclerosis. An association exists between the alterations of liver markers and the risk of coronary heart disease (CHD). This study was designed to investigate the status of oxidative stress and liver markers in patients with CHD. Methods: This study included 50 CHD patients and 50 healthy volunteers. Serum activities of glutathione peroxidase (GPX), catalase (CAT), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO), and fasting blood sugar (FBS) concentrations were measured. The Unpaired Student's t-test was used to analyze the data. Results: Serum GSH level and CAT and GPX activities were significantly greater in healthy controls than in CHD patients. Serum MDA, NO, and FBS levels and GGT, ALT, ALP activities were significantly greater in CHD patients than in healthy controls. Serum AST activity was greater in CHD patients than in controls, but the difference was not statistically significant. Conclusions: Our results indicate that CHD is related to oxidative stress, lipid peroxidation, inflammation, and elevated liver enzyme activity. CHD is a deadly disease that requires appropriate medical care. Antioxidant treatment might inhibit disease progression.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 20 May 2019 06:43
Last Modified: 20 May 2019 06:43
URI: http://eprints.lums.ac.ir/id/eprint/1716

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