Phytochemical profiles and antibacterial activities of Origanum vulgare and Hypericum perforatum and carvacrol and hypericin as a promising anti-Staphylococcus aureus

Bahmani, Mahmoud and Taherikalani, Morovat and Khaksarian, Mojtaba and Soroush, S and Ashrafi, B and Heydari, R (2019) Phytochemical profiles and antibacterial activities of Origanum vulgare and Hypericum perforatum and carvacrol and hypericin as a promising anti-Staphylococcus aureus. Mini Rev Med Chem.

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Official URL: http://www.eurekaselect.com/169205/article

Abstract

OBJECTIVES: Staphylococcus aureus, a Gram-positive bacteria, is ranked second among the causes of hospital infections and is one of the three main causes of food poisoning. In recent times, the spread of antibiotic resistance in S. aureus has become very worrisome. Therefore, research for new effective drugs is important. The present study aims to investigate the phytochemical profiles and antibacterial effects of hydroalcoholic extracts of Origanum vulgare (Lamiaceae family) and Hypericum perforatum (Clusiaceae family) and their active compounds on S. aureus (ATCC 12600) in vitro. METHODS: The identification of phytochemical compounds in both plants was performed by High-performance liquid chromatography (HPLC), headspace-solid-phase microextraction (HS-SPME) and Fourier-transform infrared spectroscopy (FTIR). To investigate microbial susceptibility, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and disc diffusion method (DAD) were used. Finally, the results of the study were compared with methicillin. RESULTS: Of the 42 combinations of O. vulgare, carvacrol (48%) and of the 38 combinations of H. perforatum, hypericin (46.2%) were the most abundant. The MIC, MBC and DAD of O. vulgare and H. perforatum, carvacrol, hypericin and methicillin were 625, 625, 312.5, 78.12 and 384 μg/mL, 10000, 10000, 2500, 2500 and 384 μg/mL, and 15.66 ± 4.49, 12.66 ± 0.47 and 22 ± 0.81 mm, respectively. CONCLUSIONS: Due to the significant effects of O. vulgare and H. perforatum and their active components against S. aureus, it is expected that in the future, hypericin, carvacrol and their derivatives can be used as effective antibacterial agents against S. aureus

Item Type: Article
Subjects: R Medicine > RZ Other systems of medicine
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: sobhan rezaiian
Date Deposited: 11 Mar 2019 08:13
Last Modified: 11 Mar 2019 08:13
URI: http://eprints.lums.ac.ir/id/eprint/1600

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